I guess I'm old school.
Ruger Speed Six .357 snub is traveling EDC on the road, whereas I may carry a smaller .38 Spl. snub at home or around town.
Six 147 grain +P+ LE or .357 JHPs in gun and one speed loader of same carry ammo on person. Two more speed loaders of 147 grain +P+ carry ammo and box of mixed ammo in GHB with 5 rds. #9 shot, and 45 rds. of .38 Special wadcutters, intended as small game "hunting" ammo.
Take-down 12-ga. riot gun, tube loaded with slugs, good to go once assembled and racked. Five 00 buckshot on butt cuff. Extra 10 rds. slug, 25 rds. buckshot, 100 rounds #6 shot in truck box with my tools. An extra box of .357 Mag. JHP or 147 +P+ .38 Spl. and four boxes of .38 Special wadcutters. Yes, .38 wadcutters are the post 9/11 substitute for .22 LR!
Since 9/11 my .22s are stashed securely in caches, lubed and cased with cleaning gear and basic load (1000 rds.) of ammo, and not routinely carried. I very seldom use a .22 anymore for anything. Not even for practice or recreation. Instead .38 Spl. Project before I retired was to load two 5-gallon buckets of .38 wadcutters for practice ammo. Works for me!
Since .22 ammo became scarce I made a serious effort to follow Harry Archer's advice long ago to have some sort of rifle which could exploit every handgun cartridge which I had four or more guns chambered for and which I kept more than 1000 rounds of ammo for.
So I ended up with lever-action cowboy guns in .38/.357, .44 Mag., .45 Colt and multiple barrels to interchange among two shotgun frames for single-shot walking guns built using the tiny pre-war H&R .410 shotgun frames. These will handle .32 S&W Long, .38 Spl., .44-40 and .45 ACP/.455 Mk1. I also have a converted Remington 580 single-shot boltgun in .32 ACP which is nearly silent and quite accurate and hard hitting compared to a .22 LR, fires a 77-grain bullet at 1200 fps or an 87-grain bullet at 1080 fps.
Future project is a .38 S&W rifle barrel to fit the "Infamous 4 lb. Bunny Gun" in which John Taylor's clever rimless extractor should allow 9mm Para to headspace on the extractor, and .38 S&W in the rim seat, using a hybrid chamber, which could accept either round in the manner of early India Model Rugers using 9mm with half-moons and .380 Mk2z or .38 S&W without... Objective is the "silent without suppressor" or "poacher's pet" using ordinary revolver ammo, but the longer barrel giving a useful increase in velocity and energy, looking at 850-900 fps with 146-158 grain lead bullet, like .38 Special revolver, but out of a light, short rifle with 20" barrel, hoping for 2" groups at 50 yards with very low noise using good ammo.