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The Power of III
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From Recombinomics
August 15, 2009

Link:
http://www.recombinomics.com/News/08150902/H274Y_SS_Confirmed.html

The presence of H274Y in a minor species would explain the failure to find H274Y in the above locations, but its presence just below the detection level in untreated patient may explain the recent increases in fatalities. Agencies have repeatedly cited the lack of H274Y detection, leading to the widespread use of Tamiflu in H1N1 in positive cases, including the two immuno-suppressed patents in the state of Washington, where H274Y was detected for the first time in the United States. In those two patients H274Y was not detected until the patients either had a reoccurrence of symptoms or a failure to respond to treatment. The resistance was found in August, even though both patients developed resistance weeks or months earlier. These detection delays and recent reports of patients, who were resistant in May and June, raise concern that the number of samples with H274Y is significantly higher that the 11 confirmed cases thus far. Media reports have described in at least one patient in Thailand, and earlier media reports described multiple cases in Texas along the Mexican border.

However, the detection of H274Y in the sample collected a few days after the start of treatment in the patient in Singapore suggests the actual incidence is much higher than the reported or withheld cases described by WHO, and a more intense screening program is critical, especially of samples collected after the start of osletamivir treatment and the increasingly common fatal cases.
 

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It's not surprising we see cases of Tamiflu resistent strains continueing and Tamiflu won't help secondary bacterial infections that seems to be the cause of many deaths in the end. I suggest having a good antibiotic on hand like Cipro for possible bacterial infections in upper respiratory tract.
 

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AKA The Dragon
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It appeares it is becoming more wide spread.

The report on these two patients follow reports of resistance in Hong Kong this week, as well as Singapore, China, and Thailand last week, in addition to media reports last week of resistance in patients in Texas at widely separated locations along the Mexican border, as well as comments from WHO on reports of resistance in an undisclosed number of patients at undisclosed locations.

On August 10, CDC received other previously collected virus isolates from this patient for testing, and pyrosequencing of a virus isolated from a specimen collected on July 14 had the H275Y mutation, confirming oseltamivir resistance.
http://bluefeeling.typepad.com/h1n1...istant-pandemic-h1n1-in-washington-state.html

Comment:

Not sure, but is this a small mutation??
 

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AKA The Dragon
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September 10, 2009

Two American campers developed Tamiflu-resistant swine flu earlier this summer, the best evidence to date that resistant pandemic viruses may have passed from one person to another, the U.S. Centers for Disease Control reported Thursday.
Viruses from both campers contained a mutation that hasn't been seen before with the pandemic virus,
a finding that heightens suspicions that drug resistant virus was either transmitted from one child to the other or that both were infected by someone else who wasn't turned up in the investigation.
http://crofsblogs.typepad.com/h5n1/...t-h1n1-may-have-spread-in-us-summer-camp.html
 
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AKA The Dragon
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2,818 Posts
Israeli lab finds Tamiflu-resistant swine flu

Jerusalem, Sep 10
Israel's Central Laboratory for Viral Infections has identified a strand of H1N1 that showed signs of resistance to the Tamiflu drug used to treat swine flu, the ministry of health said Thursday.
http://www.prokerala.com/news/articles/a78487.html

comment:

A different strain !!!!!!

But it has not mutated ????
 
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