The Power of III
more at link abovehe above report matches the demographic data for a case (28F) from Utah, which has D225G and D225N. The sample collection date also matches the date of death. The initial sequences were released at GISAID, but now the sequences are also available at GenBank. One sequence, A/Utah/42/2009 is from the original sample and has mixed signals for D225G and D225N. This combination could also code for D225S, although no such sequence has been described previously in pandemic H1N1. The second sequence is a clone which gives a clean D225G signal. The presence of sequences which can encode for D225G and D225N has not been reported previously in a single sample, but recently released CDC sequences from two patients in Ukraine had D225N, while four sequences from fatal cases released by Mill Hill had D225G. Both of the changes had been previously found in fatal cases in Sao Paulo Brazil and the recent association of these sequences with fatal or sever cases has raised concerns that the frequency of these changes is increasing, which could lead to more fatalities and severe cases in the next pandemic wave. . . .