if you want to carry with a round chambered your options are pretty limited, the George Jennings striker fired single action design(loosely based on the Walther model 9) that most Saturday night specials use isn't really safe, the HP22, taurus', berettas, PPK/S, are all safer but they are also big compared to the alternatives such as the 950 jetfire and baby browning
of course "pocket" size is really a term open to interpretation. some people can't fit a baby browning in their pockets while i consider a subcompact glock a pocket gun
my opinion is unless it's a range gun you might as well get a .32 since 22lrs are just as big with the exception of the jennings(now jimenez) all the .22lrs look to be bigger then a kel tec p32 which isn't small for a .32. the .32/380 centerfires are one of the reasons there's less 22/25 pocket guns on the market now. it seems every year .22lr pistols are steering towards target vs carry and more and more lightweight 380's come out
i don't want to throw this thread off topic but i had to say that
of course if it is solely a range gun size and safety with one in the pipe are nowhere near as big of factors. in which case that hp22 is really nice for the price.