Hmm. Not QUITE sure what you are asking about here, if it be permanent relocation, traffic tips, or advice on how to bug out of a major metropolitan area during a crisis. If the latter, the standard 'one size fits all' advice seems to be:
1) Boat. This only works if you've near water. Although if you have access to a major river or the sea it's pretty hard to stop you or obstruct you once you get out of weapon range.
2) Car or truck. Pretty self-explainatory. Not good in the event of roadblocks, gridlock, EMP, lack of gas, etc, etc.
3) ATV, motorbike, bicycle. You can go around most obstactales, follow alternative routes (railroad tracks, concrete river channels, or powerline right of ways, for instance), go pretty far on limited fuel, that sort of thing.
4) Private planes or ultralights. The sky's the limit. If you can reach the plane and take off, have enough fuel, and know how to fly, of course.
5) Your feet. The ultimate all terrain vehicle. Not fast, not easy, a bit on the exposed side, but it's REALLY hard to stop you.