Wow...that's an incredibly broad question. Could you tell us why you are buying the rifle? Hunting, self defense, target, competition? What is your skill level? Do you have a caliber in mind? What type of action...bolt action, semi auto? What is your price range?
There are literally thousands of options and nobody can give you good advice without knowing a bit more. Right now I think the only suggestion I could make is to start reading, go to a gun range and rent, ask questions at the local gun shop, take a NRA gun safety course. Basically, you need to do some research just to know what's available and narrow the search a little.