I'd probably bulletproof it.
dmzline is correct. Get a good gauge set. I watch my water temp/oil temp differential like a hawk. Careful monitoring can tell you if you have a egr failure in your near future.
I like to watch egt temps when towing as well.
Edge has a nice monitor. You can set your own alarms at whatever temp you choose. Plugs into the OBD port. I added the EGT sensor.
Easy install. Money well spent.
http://edgeproducts.com/products/insight-cs-83730/
My 6.0 has been towed heavy and has been good to me. My dad was full time RVing with his 6.0 with a 16k fifth wheel for years with no problems.
His problems started when he got the 6.4 diesel. Long story, numerous cab off repairs.
It seems like the 6.0s are good or terrible. I wouldn't chip one that was stock.
If it weren't for the EPA, we could have a diesel without all of the emission related failures. If you could remove the emissions equipment the 6.0 is a decent motor.
I miss my 7.3 diesel.....