A stock 10/22, in my opinion, is most hampered in being accurate by its trigger. They're easily 7-8 lbs. (or more) stock.
The stock rifles are great overall, though, if undersized for adults. My 10/22 stock was a fine tool for hunting, but was at best a 2 MOA gun (with me as the shooter).
With a GM bull barrel, VQ trigger group, a bipod and a scope, it's now a sub-.75 MOA gun (10-shot, 1-hole .375" groups at 50 yds.). It's probably even better than that, but mine is most hampered by the guy behind the trigger. I'm reasonably certian it could do .5 MOA with a better trigger puller.
Unfortunately, there's always a trade-off with accuracy. The tighter chamber on the GM bull barrel leads to a few more feeding problems from time to time, especially with bulk ammo. My rifle also likes the standard velocity round-nosed Wolf MT the best, which isn't the most efficient hunting ammo, and it's pricey. Also, the stock rifle, which was <5 lbs. I think, is now north of 8 lbs I'm guessing.
I think these rifles are loads of fun to plink and hunt with, but you're going to drop a load of coin to make one super accurate, particularly compared to bolt rifles. Cost wise, there's better .22LR stock semi-auto rifles too (Marlin 60, 795, etc.).
Still, I had lots of fun building up my 10/22. I get a kick out of having something built/assembled by me, to fit me perfectly. I have a Thompson Center .22 Classic that is a better rifle, but I never liked it nearly as much as my 10/22.
Of course, now I have a $600 .22 rifle. Some people say "Why?" to that. I say, "Why not?".

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